From SNPedia
rs10492972 is a SNP in the
KIF1B gene, which encodes a neuroprotein.
A genome-wide association study of 2,679 patients with multiple sclerosis (and 3,000+ controls) concluded that the rs10492972(C) allele is a risk allele for the disease, with an odds ratio of 1.35 (p = 2.5 x 10e-10). This is one of the few SNPs associated with multiple sclerosis that is not related to immune function. [PMID 18997785]
| ? | (C;C) (C;T) (T;T) |
|---|
 |
Related to MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO, 4; MS4
according to
omim 612596. See
also
| PharmGKB | PA162360096 |
| Name | |
| Annotation | In a GWAS this rs10492972[C] variant located in the KIF1B gene was associated with multiple sclerosis. |
| Gene | KIF1B |
| Featue | |
| Evidence | PubMed ID:18997785 |
| Drugs | |
| Diseases | Multiple Sclerosis |
| Curation Level | Curated |
[PMID 20067515] Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort
