rs10485057
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;G) | normal? | |
| (G;G) | 3 | increased risk for smoking, nicotine dependence |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 154092120 |
| Gene | OPRM1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10485057 |
| dbSNP (classic) | rs10485057 |
| ClinGen | rs10485057 |
| ebi | rs10485057 |
| HLI | rs10485057 |
| Exac | rs10485057 |
| Gnomad | rs10485057 |
| Varsome | rs10485057 |
| LitVar | rs10485057 |
| Map | rs10485057 |
| PheGenI | rs10485057 |
| Biobank | rs10485057 |
| 1000 genomes | rs10485057 |
| hgdp | rs10485057 |
| ensembl | rs10485057 |
| geneview | rs10485057 |
| scholar | rs10485057 |
| rs10485057 | |
| pharmgkb | rs10485057 |
| gwascentral | rs10485057 |
| openSNP | rs10485057 |
| 23andMe | rs10485057 |
| SNPshot | rs10485057 |
| SNPdbe | rs10485057 |
| MSV3d | rs10485057 |
| GWAS Ctlg | rs10485057 |
| GMAF | 0.09917 |
| Max Magnitude | 3 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs10485057 is a SNP in the opioid receptor, mu 1 OPRM1 gene.
A study of 688 Caucasian smokers (and non-smoking controls) indicated that the rare rs10485057(G) allele was associated with higher likelihood of smoking initiation and nicotine dependence. [PMID 16887046
]
[PMID 24766998] Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents
[PMID 26042510] Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population
