From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
2.2
|
increased risk of exercise induced ischemia, Increased CCL2 levels; increased rate of HIV progression
|
| (C;T)
|
2
|
increased risk of exercise induced ischemia
|
| (T;T)
|
0
|
normal risk
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
, also known as the -2578A>G SNP due to its position in the promoter of the monocyte chemoattractant protein-1 MCP-1
CCL2 gene, influences the production of its corresponding protein, a chemokine involved in inflammatory responses.
In a study focusing on 679 apparently healthy siblings of people with premature heart disease, investigators found that carriers of an rs1024611(C) allele - oriented as in dbSNP, not as published - independently predicted the risk of exercise induced ischemia in general. The odds ratio was reported to be 1.86 (CI: 1.14-3.04, p=0.014), regardless of race, age, sex and other factors. However, it is not clear if this risk carries over to individuals who lack siblings with heart disease.[PMID 16934270]
discussed in the spittoon as being relevant to HIV
[PMID 19032966] rs1024611 is not associated with systemic sclerosis in a multicenter study of 345 European patients
| OMIM | 607948 |
| Desc | MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO |
| Variant | |
| Related | also |
[PMID 22142522] Lack of Association between rs1024611 (-2581 A/G) Polymorphism in CC-chemokine Ligand 2 and Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeast Iran
[PMID 22117412] [Association of polymorphic markers of CCL2 gene with essential hypertension]
[PMID 22384203] MCP1 SNPs and Pulmonary Tuberculosis in Cohorts from West Africa, the USA and Argentina: Lack of Association or Epistasis with IL12B Polymorphisms
