From SNPedia
| Genotype | Effect |
|---|
| rs1024611(C;C) | increased risk of exercise induced ischemia, Increased CCL2 levels; increased rate of HIV progression |
| rs1024611(C;T) | increased risk of exercise induced ischemia |
| rs1024611(T;T) | normal risk |
, also known as the -2578A>G SNP due to its position in the promoter of the monocyte chemoattractant protein-1 MCP-1
CCL2 gene, influences the production of its corresponding protein, a chemokine involved in inflammatory responses.
In a study focusing on 679 apparently healthy siblings of people with premature heart disease, investigators found that carriers of an rs1024611(C) allele - oriented as in dbSNP, not as published - independently predicted the risk of exercise induced ischemia in general. The odds ratio was reported to be 1.86 (CI: 1.14-3.04, p=0.014), regardless of race, age, sex and other factors. However, it is not clear if this risk carries over to individuals who lack siblings with heart disease.[PMID 16934270]
discussed in the spittoon as being relevant to HIV
[PMID 19032966] rs1024611 is not associated with systemic sclerosis in a multicenter study of 345 European patients
| ? | (C;C) (C;T) (T;T) |
|---|
 |
Related to CHEMOKINE, CC MOTIF, LIGAND 2; CCL2
according to
omim 158105. See
also
Related to MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
according to
omim 607948. See
also
