Promethease 0.1.82
Rs1024611
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1024611 |
| hapmap | rs1024611 |
| hgdp | rs1024611 |
| ensembl | rs1024611 |
| gopubmed | rs1024611 |
| scholar | rs1024611 |
| rs1024611 | |
| pharmgkb | rs1024611 |
| hgvbaseg2p | rs1024611 |
| medrefsnp | rs1024611 |
| 23andMe | rs1024611 |
| SNP Nexus |
| Gene | CCL2 |
| Chromosome | 17 |
| Orientation | minus |
| Position | 29603901 |
| Genotype | Effect |
|---|---|
| rs1024611(C;C) | increased risk of exercise induced ischemia, Increased CCL2 levels; increased rate of HIV progression |
| rs1024611(C;T) | increased risk of exercise induced ischemia |
| rs1024611(T;T) | normal risk |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs1024611(C;C) | 2.22.2 | increased risk of exercise induced ischemia, Increased CCL2 levels; increased rate of HIV progression |
| Rs1024611(C;T) | 22 | increased risk of exercise induced ischemia |
| Rs1024611(T;T) | 00 | normal risk |
In a study focusing on 679 apparently healthy siblings of people with premature heart disease, investigators found that carriers of an rs1024611(C) allele - oriented as in dbSNP, not as published - independently predicted the risk of exercise induced ischemia in general. The odds ratio was reported to be 1.86 (CI: 1.14-3.04, p=0.014), regardless of race, age, sex and other factors. However, it is not clear if this risk carries over to individuals who lack siblings with heart disease.[PMID 16934270]
discussed in the spittoon as being relevant to HIV
[PMID 19032966] rs1024611 is not associated with systemic sclerosis in a multicenter study of 345 European patients
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
Related to CHEMOKINE, CC MOTIF, LIGAND 2; CCL2
according to omim 158105. See also
Related to MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
according to omim 607948. See also
tuberculosis
