From SNPedia
Several tightly linked SNPs in the
STAT4 gene have been linked to risk for risk haplotype for systemic lupus erythematosus (
SLE). The strongest association is found for either of two perfectly linked SNP alleles,
rs10181656(G) and
rs7582694(C), both yielding an odds ratio of 1.71 in this study of ~700 Swedish SLE patients.[
PMID 18579578]
The risk for SLE was also calculated to increase as a function of the total number of risk alleles for this SNP plus 2 others in the IRF5 gene. Compared to individuals with 0 or 1 risk alleles, the risk for SLE increased 1.82-fold for each additional risk allele from this group. The odds ratio for SLE is 2.08 (CI: 1.53-2.83) for carriers of 2 risk alleles, and goes up to 13.0 (CI: 3.78-44.3) for carriers of 5 or 6 risk alleles (compared to those with 0 or 1).
[PMID 18579578]
| ? | (C;C) (C;G) (G;G) |
|---|
 |
Related to SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4; STAT4
according to
omim 600558. See
also
[PMID 19737838] A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor
[PMID 19762360] A STAT4 risk allele is associated with ischemic cerebrovascular events and antiphospholipid antibodies in Systemic Lupus Erythematosus
[PMID 20176035] Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease
