Plavix

From SNPedia

Plavix, the trade name for clopidogrel, is a medication used to reduce the risk of heart attacks and strokes in individuals with heart disease.See also: the Wikipedia article on clopidogrel.

Because Plavix inhibits CYP2C9 at high doses, it may interfere with the metabolism of drugs processed by the liver enzyme CYP2C9, and individuals with CYP2C9 SNP variants that encode lower metabolizers to begin with would presumably be at greater risk for such side-effects when taking Plavix at the same time as drugs metabolized by CYP2C9.

SNPs influencing the metabolism (or effectiveness) of Plavix include:

• rs4244285: patients who are prescribed Plavix and who carriers of this CYP2C19*2 SNP are at 3-4x increased risk for heart attacks or other adverse cardiovascular events [PMID 19108880][PMID 19106083][PMID 19106084]