Lumbar disc disease
From SNPedia
Lumbar disc disease (LDD) is one of the causes of lower back pain, accounting for perhaps 1/3rd of back problems (according to Wikipedia).
Several studies have found genetic predispositions for LDD, often in collagen genes. The SNPs identified to date include:
- rs2073711, a SNP in the CILP gene
- rs1676486, a SNP in the COLL11A1 gene
- rs61734651, a SNP in the COL9A3 gene known as Arg103Trp or as the Trp3 allele, giving rise to an odds ratio of 2.7 (p=0.000013)[PMID 11308397]
