APOB
From SNPedia
| is a | gene |
| is | mentioned by |
| wikipedia | APOB |
| APOB | |
| gopubmed | APOB |
| 23andMe | APOB |
dbSNP 338
PubMed 338
SADR 338
HugeNav 338
HEFalMp APOB
| Chromosome position | Summary | |
|---|---|---|
| Rs1042031 | 2107925721,079,257 | |
| Rs1042034 | 2107878521,078,785 | |
| Rs1367117 | 2111740421,117,404 | |
| Rs520354 | 2111311621,113,116 | |
| Rs568413 | 2108897921,088,979 | |
| Rs5742904 | 2108266421,082,664 | |
| Rs673548 | 2109104821,091,048 | |
| Rs679899 | 2110441821,104,418 | |
| Rs693 | 2108569921,085,699 |
The apolipoprotein B gene, APOB, encodes a protein implicated in cholesterol metabolism and thus - potentially - heart disease risk.
A study of 9,000+ Danish adults was conducted to determine if APOB SNPs affected low density cholesterol (LDL) levels or heart disease risk. While SNPs did affect LDL levels, they did not have statistically significant effects on overall risk for ischemic heart disease.[PMID 18160469]
The APOB SNPs associated with LDL cholesterol increases were (dbSNP rs#'s TBD):
- T71I
- Ivs181708g>t
- T2488Tc>t
- R3611
The APOB SNPs associated with LDL cholesterol decreases were:
- Ivs4+171c>a
- A591V
- Ivs18+379a>c
- P2712L
- E4154
- N4311S
