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Factor XI deficiency

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Factor XI deficiency causes a type of bleeding disorder known as a hemophilia, in this case, hemophilia C.

More than 150 mutations that can cause hemophilia are known to occur in the gene for blood clotting factor XI. About 1 in 23 Ashkenazi Jews carries one of three relatively common factor XI mutations. Carriers usually do not develop overt disease, however, the relationship between the amount of factor XI in a person's blood and the severity of any symptoms is unclear. People with only a mild deficiency in factor XI can have serious bleeding episodes, and the symptoms can vary widely, even among family members.[1]

23andMe tests for the following SNPs associated with factor XI deficiency: