Sleep disorder
From SNPedia
Several sleep disorders and related circadian rhythm sleep disorders (CRSDs) are influenced by genetic predispositions and are defined by persistent or recurrent disturbed sleep–wake cycles. There several types, including:
Delayed sleep phase type (DSPT): characterized by significantly delayed sleep timing
- Delayed Sleep Phase Syndrome, susceptibility
- rs28936679 in the AANAT gene
- rs184039278, in the CRY1 gene
- rs10462020/rs10462021 haplotype, in the PER3 gene
Advanced sleep phase type (ASPT): characterized by extremely early involuntary sleep timing
- Familial Advanced Sleep Phase syndrome (FASPS or FASPS1)
- rs121908635 in the PER2 gene; autosomal dominant
- rs150812083 and rs139315125 in the PER3 gene
- Familial Advanced Sleep Phase syndrome 2 (FASPS2)
- rs104894561 in the CSNK1D gene; autosomal dominant
- rs397514693 in the CSNK1D gene; autosomal dominant
Free-running type (FRT): characterized by sleep timing that occurs with a 30-min to 1-h delay each day.
- Narcolepsy - see this SNPedia page for details
- Short Sleep
- rs121912617, in the DEC2 gene; autosomal dominant
- Familial natural short sleep (FNSS)
- rs1406844918, in the NPSR1 gene; autosomal dominant
Normal sleep duration or day/night preferences may be influenced by genetic factors as well; SNPs reported to influence average sleep duration or diurnal preference include:
- rs11046205, in the ABCC9 gene
- rs228697 in the PER3 gene
Sleep/wake Fragmentation:
