SLC16A11
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | solute carrier family 16, member 11 |
| EntrezGene | 162515 |
| PheGenI | 162515 |
| VariationViewer | 162515 |
| ClinVar | SLC16A11 |
| GeneCards | SLC16A11 |
| dbSNP | 162515 |
| Diseases | SLC16A11 |
| SADR | 162515 |
| HugeNav | 162515 |
| wikipedia | SLC16A11 |
| SLC16A11 | |
| gopubmed | SLC16A11 |
| EVS | SLC16A11 |
| HEFalMp | SLC16A11 |
| MyGene2 | SLC16A11 |
| 23andMe | SLC16A11 |
| UniProt | Q8NCK7 |
| Ensembl | ENSG00000174326 |
| # SNPs | 5 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs117767867 | 1.5 | 7,043,011 | |
| rs13342232 | 0 | 7,042,621 | |
| rs13342692 | 0 | 7,042,968 | |
| rs75418188 | 0 | 7,042,164 | |
| rs75493593 | 0 | 7,041,768 |
Sequence Variants in SLC16A11 Are a Common Risk Factor for Type 2 Diabetes in Mexico <http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12828.html>
A haplotype of four SNPs in this gene, common in Native Americans, may have originated in Neanderthals.
- rs117767867 is considered the tag SNP
- rs13342692
- rs75418188
- rs75493593
This haplotype raises the risk by 25% in heterozygotes and 50% in homozygotes for type-2 diabetes, and it may also lead to the development of type-2 diabetes at a younger age and lower BMI. This haplotype is found at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in Europeans and Africans.
