rs689465

minus

Geno	Mag	Summary
(A;A)		1.5x increased risk for mild asthma
(A;G)		1.35x increased risk for asthma
(G;G)		normal

Reference

GRCh38 38.1/141

Chromosome

1

Position

186681714

Gene	PACERR, PTGS2

is a	snp
is	mentioned by
dbSNP	rs689465
dbSNP (classic)	rs689465
ClinGen	rs689465
ebi	rs689465
HLI	rs689465
Exac	rs689465
Gnomad	rs689465
Varsome	rs689465
LitVar	rs689465
Map	rs689465
PheGenI	rs689465
Biobank	rs689465
1000 genomes	rs689465
hgdp	rs689465
ensembl	rs689465
geneview	rs689465
scholar	rs689465
google	rs689465
pharmgkb	rs689465
gwascentral	rs689465
openSNP	rs689465
23andMe	rs689465
SNPshot	rs689465
SNPdbe	rs689465
MSV3d	rs689465
GWAS Ctlg	rs689465

GMAF

0.1171

Max Magnitude

0

rs689465 is a SNP in the PTGS2 gene, also known as COX-2, that has been associated with increased risk for mild asthma based on a study of 663 Australian patients. The odds ratio for mild asthma associated with (A;A) genotypes was 1.5 (CI: 1.12-2.02, p=0.02).[PMID 18489027]

[PMID 18085997] Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

[PMID 21304218] Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.

[PMID 21538574] Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer.

[PMID 21848701] Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population.

[PMID 22037828] Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features.

[PMID 24789723] Cyclooxygenase-2 Polymorphisms and Breast Cancer Associated Risk in Pakistani Patients