| Geno
|
Mag
|
Summary
|
| (A;A)
|
|
1.4x increased risk for stroke
|
| (A;G)
|
|
1.4x increased risk for stroke
|
| (G;G)
|
0
|
normal risk
|
A common SNP only in Asian populations, this SNP and a close neighbor also in PRKCH gene, rs3783799, have been associated with higher risk for subcortical silent brain infarction, a common form of stroke.
The odds ratio for carriers of a risk allele is 1.27 (CI: 1.09-1.48, p=0.0026) compared to individuals homozygous for the non-risk allele, based on studies of ~300 Japanese patients. [PMID 18164711]
[PMID 20602195] PRKCH gene polymorphism is associated with the risk of severe gastric atrophy
[PMID 19703523] Association of PRKCH gene with lacunar infarction in a local Chinese Han population.
