| Geno
|
Mag
|
Summary
|
| (C;C)
|
7
|
IN*B/B Indian Blood Group; possible donor of very rare blood type
|
| (C;G)
|
3
|
Carrier of a single IN*A Indian Blood Group allele
|
| (G;G)
|
0
|
Indian Blood Group IN*B/B
|
Known more commonly as either 252G>C or Arp46Pro (R46P), the rs369473842(C) variant leads to the absence of the Indian B antigen, at least when present in two copies. The absence of the Indian B antigen leads to the IN*A/A phenotype, is generally only observed (rarely) in people of Pakistani, Indian or Iranian descent.
One appeal for IN*A/A donors (of blood type O or A) to help a 2 year old child requiring blood transfusions has been posted by OneBlood. In SNP nomenclature, and therefore in Promethease reports, this would be reported as rs369473842(C;C).
Note: an incorrect assignment of a different SNP (rs121909545) to this variant is reported in OMIM, ClinVar and some other databases.
