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rs326

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 lower HDL cholesterol
(A;G) lower HDL cholesterol
(G;G) normal risk
ReferenceGRCh38 38.1/141
Chromosome8
Position19961928
GeneLPL
is asnp
is mentioned by
dbSNPrs326
dbSNP (classic)rs326
ClinGenrs326
ebirs326
HLIrs326
Exacrs326
Gnomadrs326
Varsomers326
LitVarrs326
Maprs326
PheGenIrs326
Biobankrs326
1000 genomesrs326
hgdprs326
ensemblrs326
geneviewrs326
scholarrs326
googlers326
pharmgkbrs326
gwascentralrs326
openSNPrs326
23andMers326
SNPshotrs326
SNPdbers326
MSV3drs326
GWAS Ctlgrs326
GMAF0.3457
Max Magnitude2
? (A;A) (A;G) (G;G) 28


The (A) allele of rs326 was associated with risk for lower high-density lipoprotein (HDL) cholesterol plasma levels in 3 independent population samples, including both Caucasians and African-Americans.[PMID 17952847OA-icon.png]

GWAS snp
PMID [PMID 18193046]
Trait Triglycerides
Title Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
Risk Allele A
P-val 4.9999999999999997E-12
Odds Ratio 6.60 [3.66-9.54] % higher
OMIM609708
DescLIPOPROTEIN LIPASE; LPL
Variant
Relatedalso


OMIM609708
Desc
Variant0042
Relatedalso


[PMID 21149302OA-icon.png] Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population


[PMID 15980532OA-icon.png] SOP3v2: web-based selection of oligonucleotide primer trios for genotyping of human and mouse polymorphisms.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 20150529OA-icon.png] Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study.


GWAS snp
PMID [PMID 23726366OA-icon.png]
Trait Triglycerides
Title Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
Risk Allele T
P-val 1E-8
Odds Ratio .04 [NR] unit decrease


ClinVar
Risk Rs326(G;G)
Alt Rs326(G;G)
Reference Rs326(A;A)
Significance Other
Disease High density lipoprotein cholesterol level quantitative trait locus 11
Variation info
Gene LPL
CLNDBN High density lipoprotein cholesterol level quantitative trait locus 11
Reversed 0
HGVS NC_000008.10:g.19819439A>G
CLNSRC OMIM Allelic Variant
CLNACC RCV000001625.2,