rs2236225(C;T)

Possible increased risk of birth defects

Is a	genotype
of	rs2236225
Gene	MTHFD1
Chromosome	14
Position	64,442,127
mentioned	by

Magnitude

1.25

Repute

Bad

Geno	Mag	Summary
(C;C)	0	common/normal
(C;T)	1.25	Possible increased risk of birth defects
(T;T)	1.5	Slightly (~1.5x) higher risk for Caucasian mothers to give birth to NTD children

Some studies, predominanty amongst Caucasians, have shown that presence of this mutation is associated with a slightly higher risk to give birth to children with neural tube defects; other studies have demonstrated association with heart defects in homozygous offspring - See discussion at rs2236225.