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From SNPedia

Geno Mag Summary
(A;A) 0
Make rs1801275(A;G)
Make rs1801275(G;G)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs1801275
1000 genomesrs1801275
GWAS Ctlgrs1801275
Max Magnitude0
? (A;A) (A;G) (G;G) 28


[PMID 19515749] Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial

[PMID 19956098OA-icon.png] Association analysis of SNPs in the IL4R locus with type I diabetes

[PMID 21196282] Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma

[PMID 21734400] Attempted Replication of 50 Reported Asthma Risk Genes Identifies a SNP in RAD50 as Associated with Childhood Atopic Asthma

[PMID 22119518] Interleukin-4 receptor alpha polymorphisms in autoimmune myasthenia gravis in a Caucasian population

GWAS snp
PMID [PMID 22075330OA-icon.png]
Title A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
Risk Allele G
P-val 1E-7
Odds Ratio 0.0500 None

Risk rs1801275(G;G)
Alt rs1801275(G;G)
Reference Rs1801275(A;A)
Significance Other
Disease Atopy
Variation info
Gene IL4R
CLNDBN Atopy, susceptibility to
Reversed 0
HGVS NC_000016.9:g.27374400A>G
CLNSRC OMIM Allelic Variant UniProtKB (protein)
CLNACC RCV000015775.3,

[PMID 15660293OA-icon.png] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16024651OA-icon.png] Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.

[PMID 16759385OA-icon.png] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

[PMID 16842617OA-icon.png] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.

[PMID 17083349] Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 17940599OA-icon.png] Assembly of inflammation-related genes for pathway-focused genetic analysis.

[PMID 18006935] An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.

[PMID 18625055OA-icon.png] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.

[PMID 18781131OA-icon.png] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19956101OA-icon.png] Overview of the Rapid Response data.

[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

[PMID 20298583OA-icon.png] Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 22045834] Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.

[PMID 22369735] Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma.

[PMID 23480403] Case-control study of eczema in relation to IL4Rα genetic polymorphisms in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

[PMID 23299779OA-icon.png] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma

[PMID 23924473] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma

[PMID 23979976] Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk

[PMID 23996684OA-icon.png] Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry

[PMID 22902050OA-icon.png] Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma.

[PMID 23395224] Association between polymorphisms in interleukin-4Ralpha and interleukin-13 and glioma risk: a meta-analysis.

[PMID 25110223] rs1801275 Interleukin-4 receptor alpha polymorphism in familial hypercholesterolemia

[PMID 25785117OA-icon.png] Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis

[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal

[PMID 28289589OA-icon.png] Polymorphism of the IL13 gene may be associated with Uterine leiomyomas in Slovenian women.

[PMID 30227113] Association study on IL-4, IL-4Rα and IL-13 genetic polymorphisms in Swedish patients with colorectal cancer.

[PMID 31264107] Association between interleukin-4 and interleukin-10 single nucleotide polymorphisms and multiple sclerosis among Iraqi patients.