rs16991615

plus

Geno	Mag	Summary
(A;A)	1.5	age at menopause increased by avg of 22 months
(A;G)	1.5	slight increase (11 months) in avg age at menopause
(G;G)	0	common on affy axiom data

Reference

GRCh38 38.1/141

Chromosome

20

Position

5967581

Gene

MCM8

is a	snp
is	mentioned by
dbSNP	rs16991615
dbSNP (classic)	rs16991615
ClinGen	rs16991615
ebi	rs16991615
HLI	rs16991615
Exac	rs16991615
Gnomad	rs16991615
Varsome	rs16991615
LitVar	rs16991615
Map	rs16991615
PheGenI	rs16991615
Biobank	rs16991615
1000 genomes	rs16991615
hgdp	rs16991615
ensembl	rs16991615
geneview	rs16991615
scholar	rs16991615
google	rs16991615
pharmgkb	rs16991615
gwascentral	rs16991615
openSNP	rs16991615
23andMe	rs16991615
SNPshot	rs16991615
SNPdbe	rs16991615
MSV3d	rs16991615
GWAS Ctlg	rs16991615

GMAF

0.03489

Max Magnitude

1.5

?

(A;A) (A;G) (G;G)

28

rs16991615 is a nonsynonymous SNP on chromosome 20.

A case control study of ~2,000 women found that each rs16991615(A) allele was associated with an average increase in age at menopause of 11 months. This also meant that each rs16991615(G) allele yielded an odds ratio of 1.85 (CI: 1.51–2.2, p = 1.45 x 10e-9) of early menopause, defined as occurring before the age of 46.[PMID 20952801 ]

Overall, women homozygous for the "early" alleles at all 4 SNPs found in this study were ~4 times more likely to undergo menopause early compared to women who had a total of 3 or less risk alleles. However, the ability to predict which women will actually undergo early menopause using these 4 SNPs is still low.[PMID 20952801 ]

see also 23andMe blog

GWAS snp
PMID	[PMID 19448621 ]
Trait	Menarche and menopause (age at onset)
Title	Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
Risk Allele	A
P-val	1E-21
Odds Ratio	1.07 [0.85-1.29] years older

OMIM	612885
Desc
Variant
Related	also

GWAS snp
PMID	[PMID 22267201 ]
Trait
Title	Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Risk Allele	A
P-val	0
Odds Ratio	0.9480 None

[PMID 18535201 ] A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.

[PMID 19664201 ] Genetic and genomic insights into age at natural menopause.

[PMID 23508249 ] Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study

[PMID 23592221] Shared genetic factors for age at natural menopause in Iranian and European women

GWAS snp
PMID	[PMID 23307926 ]
Trait	Menopause (age at onset)
Title	A genome-wide association study of early menopause and the combined impact of identified variants.
Risk Allele	A
P-val	5E-12
Odds Ratio	.46 [0.33-0.59] years decrease

[PMID 29073238 ] Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study.

[PMID 33497044 ] Genetic Determinants of Premature Menopause in A Mashhad Population Cohort.