| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
normal
|
| (A;G)
|
1.4
|
1.4x higher risk for colorectal cancer
|
| (G;G)
|
2
|
1.9x higher risk for colorectal cancer
|
rs16888589 is a SNP on ch 8q23 near the EIFH3 gene, and it appears to be able to influence the amount of EIFH3 protein made.
rs16888589 may have a causative role in increasing the risk for colorectal cancer; specifically, the minor (i.e. less frequent) rs16888589(G) allele is associated with more EIFH3 protein, in turn associated with more cancerous cell growth and invasiveness. In a statistical sense, the rs16888589(G) allele is associated with a 1.4 - 2 fold increase in risk. The authors of this study also conclude that several other nearby SNPs (rs16892766 and rs11986063) that have been statistically linked to higher colorectal cancer risk are part of a tightly linked haplotype with rs16888589, i.e. they are often inherited together, but these other SNPs are not likely to be causative since on their own in in vitro experiments they do not influence EIFH3 protein amounts.10.1371/journal.pgen.1001126
[PMID 21314996
] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
