Pain

Several genes (and the SNPs within them) are known to influence perception to pain [PMID 23545734]. The genes include:

• ADRB2
• COMT
• HLA/MHC region
• FAAH
• HTR2A
• NGF
• NTRK1
• SCN9A; see in particular insensitivity to pain
• SCN10A
• SCN11A
• SERPINA1
• SLC6A4
• TRPA1
• ZFHX2

and the SNPs include, among plenty of others:

rs6269 rs4633 rs4818 rs4680

rs6746030 [PMID 20212137]

See also genosets gs232, gs233, gs234 and gs235 which evaluate likely pain categories (low, average, high) for Promethease users based on one COMT-gene based schema.