Depression

For a fine introduction to clinical depression, see Wikipedia's entry. Note that there are distinct types of depression, and studies of genetic influences typically focus on one type.

SNPs may play a role in predisposing an individual to depression and also in how patients respond to anti-depressant medications.

SNPs potentially predisposing individuals to depression include (in no particular order):

rs729861, in the PDE9A gene [PMID 17008408]
rs3770018, in the PDE11A gene [PMID 17008408]
rs1801133, in the MTHFR gene PMID 12796225, PMID 16402130]
rs1824024, in the CHRM2 gene [PMID 15229186]
rs2061174, also in the CHRM2 gene, [PMID 15229186]
rs1799913, in the TPH1 gene [PMID 16165107]
rs7933505, also in the TPH1 gene [PMID 16165107]
A '1463G-A' SNP in the TPH2 gene known as "R441H" that has no dbSNP rs# [PMID 15629698]
Six SNPs in the BCR gene are reported to correlate with depression in a Japanese population [PMID 15866548]
A SNP in the choline acetyltransferase (CHAT) gene [PMID 18603262]
rs1545843 and rs1031681, associated with the SLC6A15 gene [PMID 21521612]

SNPs potentially influencing how patients respond to anti-depressant medications include:

rs1360780, in the FKBP5 gene, also influencing risk [PMID 15565110]
rs1549870, in the PDE1A gene, with respect to desipramine or fluoxetine [PMID 17008408]
rs1880916, in the PDE11A gene, with respect to desipramine or fluoxetine [PMID 17008408]
rs7997012, in the HTR2A gene, with respect to citalopram [PMID 16642436]
rs1954787, in the GRIK4 gene, with respect to citalopram [doi: 10.1176/appi.ajp.2007.06111790]
CYP2D6 alleles influence risk for side effects from drugs such as venlafaxine(Effexor)
rs4680 influences antidepressant response of paroxetine
rs6314, in the HTR2A gene

see also OMIM entry on Major Depressive Disorder

http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3623.html Identification of 15 genetic loci associated with risk of major depression in individuals of European descent via data in excel