Abdominal aortic aneurysm
From SNPedia
The incidence of abdominal aortic aneurysm (AAA) varies among ethnic groups. Wikipedia Risk factors include genetic susceptibility, atherosclerosis, male sex, smoking, and hypertension.
If detected before rupture, a dangerously large abdominal aortic aneurysm can usually be surgically repaired. Wikipedia
Although of small effect each, SNPs reported to affect risk of abdominal aortic aneurysm and to be reasonably robust statistically include [PMID 24834361
],[PMID 26460285]:
- rs10757278, CDKN2BAS
- rs7025486, DAB2IP
- rs7529229, IL6R
- rs10455872, LPA
- rs1466535, LRP1 (slight protective effect from major allele)
- rs599839, SORT1
- rs6511720, LDLR (slight protective effect from minor allele)
SNPs that have been reported but that may not be as reproducible include:
- rs7635818, ch 3p21 (hasn't replicated that well)
- rs326118
- rs8003379
- rs1799889 (the risk genotype is the 5G insertion)
- rs333
- rs1800796 (risk allele C)
Some SNPs that were formerly thought to affect risk of AAA appear to have no effect.
