rs828907

plus

Geno	Mag	Summary
(G;G)	1	Normal risk of developing bladder cancer
(G;T)	2	Slightly increased risk of bladder cancer and 2x risk of developing bladder cancer in smokers
(T;T)	2	Increased risk of bladder cancer and 2x risk of developing bladder cancer in smokers

Reference

GRCh38 38.1/141

Chromosome

2

Position

216108009

Gene

XRCC5

is a	snp
is	mentioned by
dbSNP	rs828907
dbSNP (classic)	rs828907
ClinGen	rs828907
ebi	rs828907
HLI	rs828907
Exac	rs828907
Gnomad	rs828907
Varsome	rs828907
LitVar	rs828907
Map	rs828907
PheGenI	rs828907
Biobank	rs828907
1000 genomes	rs828907
hgdp	rs828907
ensembl	rs828907
geneview	rs828907
scholar	rs828907
google	rs828907
pharmgkb	rs828907
gwascentral	rs828907
openSNP	rs828907
23andMe	rs828907
SNPshot	rs828907
SNPdbe	rs828907
MSV3d	rs828907
GWAS Ctlg	rs828907

GMAF

0.2957

Max Magnitude

2

?

(G;G) (G;T) (T;T)

28

rs828907, also known as G-1401T, is a SNP in the Ku80 gene.

A study of 288 Chinese patients with bladder cancer and 288 age- and gender-matched healthy controls found that the rs828907(T) allele conferred a significant (p=0.0055) increased risk of bladder cancer. In association with smoking, the (G;T) and (T;T) genotypes conferred a 2x risk (CI:1.232-3.419) for bladder cancer.[PMID 19414375]

[PMID 19217823] correlated with oral cancer susceptibility

[PMID 19528488] Significant Association of Ku80 Single Nucleotide Polymorphisms with Colorectal Cancer Susceptibility in Central Taiwan

[PMID 20044645] Significant Association of DNA Repair Gene Ku80 Genotypes with Breast Cancer Susceptibility in Taiwan

[PMID 23098447] Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis