rs5029939
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common in complete genomics |
| (C;G) | 1.67x increased risk of Sjogren's syndrome | |
| (G;G) | 1.67x increased risk of Sjogren's syndrome |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 137874586 |
| Gene | TNFAIP3 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs5029939 |
| dbSNP (classic) | rs5029939 |
| ClinGen | rs5029939 |
| ebi | rs5029939 |
| HLI | rs5029939 |
| Exac | rs5029939 |
| Gnomad | rs5029939 |
| Varsome | rs5029939 |
| LitVar | rs5029939 |
| Map | rs5029939 |
| PheGenI | rs5029939 |
| Biobank | rs5029939 |
| 1000 genomes | rs5029939 |
| hgdp | rs5029939 |
| ensembl | rs5029939 |
| geneview | rs5029939 |
| scholar | rs5029939 |
| rs5029939 | |
| pharmgkb | rs5029939 |
| gwascentral | rs5029939 |
| openSNP | rs5029939 |
| 23andMe | rs5029939 |
| SNPshot | rs5029939 |
| SNPdbe | rs5029939 |
| MSV3d | rs5029939 |
| GWAS Ctlg | rs5029939 |
| GMAF | 0.123 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
An association was found between Systemic lupus erythematosus (SLE) and rs5029939 (meta-analysis p = 2.89 x 10(-12), odds ratio 2.29).[PMID 18677312]
| GWAS | |
|---|---|
| SNP | rs5029939 |
| PubMedID | [PMID 18677312] |
| Condition | Systemic lupus erythematosus |
| Gene | TNFAIP3 |
| Risk Allele | |
| pValue | 3.00E-012 |
| OR | 2.28 |
| 95% CI | |
[PMID 19387456
] Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations
| GWAS snp | |
|---|---|
| PMID | [PMID 19165918]
|
| Trait | Systemic lupus erythematosus |
| Title | PubMedID=18677312: cannot get document summary |
| Risk Allele | |
| P-val | 3E-12 |
| Odds Ratio | 2.28 [NR] |
[PMID 20511617] Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population
[PMID 21740805] Variants of tumor necrosis factor-induced protein 3 gene are associated with left ventricular hypertrophy in hypertensive patients
[PMID 19169254] Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 19849816] Genetics of rheumatic disease.
[PMID 20617138] Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population.
[PMID 22488580] Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity.
[PMID 22924496] Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.
| GWAS snp | |
|---|---|
| PMID | [PMID 24097066] |
| Trait | Sjögren's syndrome |
| Title | A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. |
| Risk Allele | G |
| P-val | 8E-9 |
| Odds Ratio | 1.67 [1.40-1.99] |
[PMID 25806576] The polymorphisms of tumor necrosis factor-induced protein 3 gene may contribute to the susceptibility of chronic primary immune thrombocytopenia in Chinese population
[PMID 26092158] IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups
[PMID 25337792] Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population
[PMID 28448618] rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population.
