rs10830963
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal risk of Type-2 Diabetes |
| (C;G) | 2.7 | increased type-2 diabetes risk; higher gestational diabetes risk |
| (G;G) | 3.1 | increased type-2 diabetes risk; higher gestational diabetes risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 92975544 |
| Gene | MTNR1B |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10830963 |
| dbSNP (classic) | rs10830963 |
| ClinGen | rs10830963 |
| ebi | rs10830963 |
| HLI | rs10830963 |
| Exac | rs10830963 |
| Gnomad | rs10830963 |
| Varsome | rs10830963 |
| LitVar | rs10830963 |
| Map | rs10830963 |
| PheGenI | rs10830963 |
| Biobank | rs10830963 |
| 1000 genomes | rs10830963 |
| hgdp | rs10830963 |
| ensembl | rs10830963 |
| geneview | rs10830963 |
| scholar | rs10830963 |
| rs10830963 | |
| pharmgkb | rs10830963 |
| gwascentral | rs10830963 |
| openSNP | rs10830963 |
| 23andMe | rs10830963 |
| SNPshot | rs10830963 |
| SNPdbe | rs10830963 |
| MSV3d | rs10830963 |
| GWAS Ctlg | rs10830963 |
| GMAF | 0.258 |
| Max Magnitude | 3.1 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 19241057] rs10830963 was associated with an increased risk of type-2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele
[PMID 19088850
] rs10830962, rs4753426, and rs10830963 were significantly associated with higher fasting plasma glucose concentrations and reduced OGTT- and IVGTT-induced insulin release. rs3781638 displayed significant association with lower fasting plasma glucose levels and increased OGTT-induced insulin release
[PMID 19324940] A study totaling 19,000+ Europeans concluded that rs10830963 had the most influence of any MTNR1B gene SNP on the risk for type-2 diabetes. Specifically, the (G) allele increased the risk of isolated impaired fasting glycemia (OR=1.64, P=5.5x10(-11)) but not isolated impaired glucose tolerance.
[PMID 21658282] 900+ patients with gestational diabetes were studied, and the rs10830963(G) SNP was postulated to perhaps be a causal SNP for the condition, with an odds ratio of ~1.3 - 1.4.
| GWAS snp | |
|---|---|
| PMID | [PMID 19060907]
|
| Trait | Fasting plasma glucose |
| Title | Variants in MTNR1B influence fasting glucose levels |
| Risk Allele | G |
| P-val | 3E-50 |
| Odds Ratio | 0.07 [0.06-0.08] mmol/l increase |
[PMID 19651812] Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites
[PMID 19741166] Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)
| GWAS snp | |
|---|---|
| PMID | [PMID 20081858]
|
| Trait | Fasting glucose-related traits |
| Title | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| Risk Allele | G |
| P-val | 0 |
| Odds Ratio | None None |
[PMID 20536959] Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort
[PMID 20802253] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
[PMID 20839289] Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
[PMID 21036910] Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
[PMID 21059861] Association of a melatonin receptor 1B (MTNR1B) gene variant with fasting glucose and HOMA-B in children and adolescents of high BMI-SDS groups
[PMID 21470412] A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals
[PMID 21949744] Effects of 16 Genetic Variants on Fasting Glucose and Type 2 Diabetes in South Asians: ADCY5 and GLIS3 Variants May Predispose to Type 2 Diabetes
[PMID 22096510] Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a chinese population
[PMID 22450346] The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population
[PMID 22508271] Fasting Glucose GWAS Candidate Region Analysis Across Ethnic Groups in the Multiethnic Study of Atherosclerosis (MESA).
[PMID 22698518] Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients
[PMID 22768333] Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women
| GWAS snp | |
|---|---|
| PMID | [PMID 22286219]
|
| Trait | |
| Title | Genome-wide association study identifies multiple loci influencing human serum metabolite levels. |
| Risk Allele | |
| P-val | 3E-11 |
| Odds Ratio | 0.1400 None |
[PMID 22768041] Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals
[PMID 19184136] Examination of association of genes in the serotonin system to autism.
[PMID 19324937] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
[PMID 19455304] Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response.
[PMID 19502414] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
[PMID 19533084] Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.
[PMID 19822575] Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.
[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
[PMID 20043853] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
[PMID 20152958] A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels.
[PMID 20398260] MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai.
[PMID 20628598] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
[PMID 20664687] Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract.
[PMID 20668700] Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 20870969] Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
[PMID 20959387] Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome.
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 21366812] Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.
[PMID 21380592] No effect by the common gene variant rs10830963 of the melatonin receptor 1B on the association between sleep disturbances and type 2 diabetes: results from the Nord-Trondelag Health Study.
[PMID 21558052] A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity.
[PMID 21711391] Association and evolutionary studies of the melatonin receptor 1B gene (MTNR1B) in the self-contained population of Sorbs from Germany.
[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
| GWAS snp | |
|---|---|
| PMID | [PMID 22581228]
|
| Trait | |
| Title | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. |
| Risk Allele | |
| P-val | 4E-105 |
| Odds Ratio | None None |
[PMID 22759724] Polymorphisms in the melatonin receptor 1B gene and the risk of delirium
[PMID 23029294] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus
[PMID 23690305] Genetic variants and the risk of gestational diabetes mellitus: a systematic review
[PMID 23840762] Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk
[PMID 24005634] [Involvement of melatonin MT2 receptor mutants in type 2 diabetes development]
[PMID 24157813] Association between Genetic Variations in MTNR1A and MTNR1B Genes and Gestational Diabetes Mellitus in Han Chinese Women
[PMID 23092954] SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.
[PMID 23456907] Maternal genotype and gestational diabetes.
[PMID 23462794] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
[PMID 23611530] Genetics of melatonin receptor type 2 is associated with left ventricular function in hypertensive patients treated according to guidelines.
[PMID 25132852] MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women
| GWAS snp | |
|---|---|
| PMID | [PMID 24509480]
|
| Trait | Type 2 diabetes |
| Title | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. |
| Risk Allele | G |
| P-val | 2E-7 |
| Odds Ratio | 1.11 [1.06-1.16] |
| GWAS snp | |
|---|---|
| PMID | [PMID 23251661]
|
| Trait | Obesity-related traits |
| Title | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
| Risk Allele | G |
| P-val | 4E-8 |
| Odds Ratio | .05 [NR] mg/dL increase |
[PMID 25707907] Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study
[PMID 25898821] The polymorphisms of melatonin receptor 1B gene (MTNR1B) (rs4753426 and rs10830963) and susceptibility to adolescent idiopathic scoliosis: a meta-analysis
[PMID 26440713] Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans
[PMID 26519818] Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese
[PMID 26551672] Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
[PMID 26563312] Relationship between melatonin receptor 1B (rs10830963 and rs1387153) with gestational diabetes mellitus: a case-control study and meta-analysis
[PMID 26912228] Insomnia does not mediate or modify the association between MTNR1B risk variant rs10830963 and glucose levels.
[PMID 27763686] Melatonin and the pathologies of weakened or dysregulated circadian oscillators.
[PMID 28072873] Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development.
[PMID 29691896] Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans.
[PMID 30834760] Association of the rs10830963 polymorphism in MTNR1B with fasting glucose, serum adipokine levels and components of metabolic syndrome in adult obese subjects.
[PMID 30981681] Dietary-fat effect of the rs10830963 polymorphism in MTNR1B on insulin resistance in response to 3 months weight-loss diets.
[PMID 31757795] Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank.
[PMID 32057567] A circadian rhythm-related MTNR1B genetic variant (rs10830963) modulate body weight change and insulin resistance after 9 months of a high protein/low carbohydrate vs a standard hypocaloric diet.
[PMID 32656703] MTNR1B gene on susceptibility to gestational diabetes mellitus: a two-stage hospital-based study in Southern China.
