Gs312
From SNPedia
| Gs312 | |
|---|---|
| Magnitude | 5.5 |
| Repute | Bad |
| Summary | Intermediate metabolizer of fluoropyrimidines (such as 5-fluorouracil and capecitabine). |
| Criteria | Gs312/criteria |
This genoset predicts the presence of one nonfunctional DPYD allele, and therefore possible toxicity risk if administered chemotherapeutic fluoropyrimidines such as 5-fluorouracil, capecitabine or tegafur. CPIC and the FDA recommend either pharmacokinetic testing and/or reduced (50%) initial dosing of such drugs in patients with one nonfunctional DPYD allele.
