|(C;C)||0||very common, but it seems better to have the minor allele which is protective against several diseases|
|(C;T)||3||resistance to several diseases|
|(T;T)||3.5||resistance to several diseases|
|?||(C;C) (C;T) (T;T)||28|
23andMe blog rs8177374(T) less susceptible to infection with malaria, tuberculosis, bacteremia and pneumococcal disease.
[PMID 19509334] Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock
|Disease||Invasive pneumococcal disease Malaria Mycobacterium tuberculosis Bacteremia|
|CLNDBN||Invasive pneumococcal disease, protection against Malaria, resistance to Mycobacterium tuberculosis, protection against Bacteremia, resistance to|
|CLNSRC||OMIM Allelic Variant UniProtKB (protein)|
|CLNACC||RCV000004722.2, RCV000004723.2, RCV000004724.2, RCV000023527.2,|
[PMID 19543401] Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
[PMID 20016852] Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.
[PMID 20525286] Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
[PMID 21274447] Genetic polymorphisms and posttraumatic complications.
[PMID 21399862] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.
[PMID 23047423] A TIR domain receptor-associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth
[PMID 22691414] Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
[PMID 24064014] TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts
[PMID 23255565] Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.
[PMID 24067789] The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis