How can this be? One explanation (10.1096/fj.06-1005ufm) suggests the following:
- Caucasians have a different distribution of this SNP than do Hispanics and African Americans;
- Having this SNP may be necessary, but is not sufficient, to cause fatty liver, as many individuals with the SNP have normal liver fat;
- Probably this SNP does slow the export of fat from liver, but only rs7946 carrying individuals who also take in too many calories too quickly (i.e. overeat) will wind up with fatty livers.
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