|(C;C)||1||Normal risk for multiple autoimmune diseases|
|(C;T)||1.5||Slightly increased risk for multiple autoimmune diseases, such as type-1 diabetes|
|(T;T)||2||Increased risk for multiple autoimmune diseases|
Based on multiple studies (by one group) now totaling over 2,000 patients, the rs763361(T) allele is associated with increased risk for multiple autoimmune diseases, including type-1 diabetes (p = 3 x 10e-9), multiple sclerosis (p = 4 x 10e-4), and possibly rheumatoid arthritis (p = 0.017). Based on tag SNP analysis, the authors conclude that this SNP could be the causal variant.[PMID 18971939]
[PMID 18987646] Tested in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10 296 unrelated controls, SNP rs763361 was associated with disease risk (p = 5.4 x 10e-8)
|Condition||Type 1 diabetes|
[PMID 19624611] The CD226 gene in susceptibility of type 1 diabetes
[PMID 19951419] Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis
[PMID 20338887] Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
[PMID 20508602] The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis
[PMID 20444755] Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment
[PMID 20669283] A 3'UTR variant is associated with impaired expression of CD226 in T and NK T cells and susceptibility to systemic lupus erythematosus
[PMID 20887380] Association of the CD226 single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han population
[PMID 20952449] Evaluation of the established non-MHC multiple sclerosis loci in an Indian population
[PMID 21286723] The CD226 gene in susceptibility of rheumatoid arthritis in the Chinese Han population
[PMID 21521299] The role of a non-synonymous CD226 (DNAX-accessory molecule-1) variant (Gly 307Ser) in isolated Addison's disease and autoimmune polyendocrinopathy type 2 pathogenesis
[PMID 22302395] Influence of MIF, CD40, and CD226 polymorphisms on risk of rheumatoid arthritis
|Title||Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.|
|Odds Ratio||1.1200 [NR]|
[PMID 22531499] A multicentre study confirms CD226 gene association with Systemic Sclerosis-related pulmonary fibrosis
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 19073967] Shared and distinct genetic variants in type 1 diabetes and celiac disease.
[PMID 19359276] Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
[PMID 20072139] Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.
[PMID 20089178] Allelic variants in the PHTF1-PTPN22, C12orf30 and CD226 regions as candidate susceptibility factors for the type 1 diabetes in the Estonian population.
[PMID 20182566] The genetic aspects of multiple sclerosis.
[PMID 20236493] The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.
[PMID 20405052] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
[PMID 21162102] Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis.
[PMID 21765104] Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.
[PMID 23073294] CD226 Gly307Ser association with multiple autoimmune diseases: A meta-analysis
[PMID 23999715] CD226 rs763361 (Gly307Ser) Polymorphism Is Associated with Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran
[PMID 23922043] Lack of association between CD226 genetic variants and inflammatory demyelinating diseases in Korean population
[PMID 22728856] CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese.
[PMID 22941566] Association between the CD226 rs763361 polymorphism and susceptibility to autoimmune diseases: a meta-analysis.
[PMID 23262348] Association between two genetic variants of CD226 gene and Cervical Squamous Cell Carcinoma: a case-control study.
[PMID 25057181] CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis
[PMID 25645050] Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis
[PMID 25661663] Association of 32 type 1 diabetes risk loci in Pakistani patients
[PMID 25891570] Evaluation of SNP rs763361 on Gly307Ser gene in multiple sclerosis patients compared to healthy subjects
[PMID 26634488] Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children.
[PMID 27440135] Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population.
[PMID 27722794] Gene-gene interaction between CD40 and CD226 gene on systemic lupus erythematosus in the Chinese Han population.
[PMID 30128676] High-resolution melting curve analysis of polymorphisms within CD58, CD226, HLA-G genes and association with multiple sclerosis susceptibility in a subset of Iranian population: a case-control study.