|(C;T)||2||~0.80x reduced cancer risk|
|(T;T)||2||~0.80x reduced cancer risk|
A meta-analysis of 19 published studies, including 11,105 cancer cases and 11,372 controls, concluded that the rs763110(C;T) and (T;T) genotypes were associated with a significantly reduced (about 0.80x) cancer risk of all cancer types.[PMID 19337311]
[PMID 19240174] Polymorphisms in the FAS and FASL genes and survival of early stage non-small cell lung cancer.
[PMID 21807637] A Polymorphic -844T/C in FasL Promoter Predicts Survival and Relapse in Non-Small Cell Lung Cancer
[PMID 22732091] FASL -844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population
|CLNDBN||LUNG CANCER, SUSCEPTIBILITY TO|
|CLNSRC||OMIM Allelic Variant|
[PMID 18757527] Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.
[PMID 18759263] Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 18854777] Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.
[PMID 19941645] Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans.
[PMID 20438363] Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans.
[PMID 20959405] The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia.
[PMID 15937082] Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer.
[PMID 23141929] A Controlled Case Study of the Relationship Between Environmental Risk Factors and Apoptotic Gene Polymorphism and Lumbar Disc Herniation
[PMID 23392773] Apoptosis-related Fas and FasL gene polymorphisms' associations with knee osteoarthritis
[PMID 24086353] FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects
[PMID 24424626] Association of genetic variants in apoptosis genes FAS and FASL with radiation-induced late toxicity after prostate cancer radiotherapy
[PMID 24587306] Death Receptor (DR4) Haplotypes Are Associated with Increased Susceptibility of Gallbladder Carcinoma in North Indian Population
[PMID 23749041] Relation of the Fas and FasL gene polymorphisms with susceptibility to and severity of rheumatoid arthritis.
[PMID 25645050] Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis
[PMID 25661359] The association between the SNP rs763110 and the risk of gynecological cancer: A meta-analysis
[PMID 26891954] Significant association between FasL gene -844T/C polymorphism and risk to hepatocellular carcinoma in Egyptian patients.
[PMID 26905515] Fas/FasL, Bcl2 and Caspase-8 gene polymorphisms in Chinese patients with rheumatoid arthritis.
[PMID 29611722] Single-Nucleotide Polymorphisms of FAS and FASL Genes and Risk of Idiopathic Aplastic Anemia.
[PMID 30065912] Variants of FasL and ABCC5 are predictive of outcome after chemotherapy-based treatment in osteosarcoma.