|up to 2.1x asthma risk via the ORMDL3 gene|
|(C;C)||2||0.69x lower risk of Childhood Asthma.|
|(C;T)||1.8||Normal risk for Childhood Asthma.|
|(T;T)||2||1.5x increased risk for Childhood Asthma.|
A large study of Scottish asthma patients replicated these results, finding that a single copy of the T allele conferred an odds ratio of 1.50 (CI: 1.24-1.81) and 2 copies conferred an odds ratio of 2.11 (CI: 1.71-2.61), respectively.[PMID 18395550]
[PMID 19029000] Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.
[PMID 20372189] A sequence variant on 17q21 is associated with age at onset and severity of asthma
[PMID 19133921] Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma
[PMID 20503266] Allergy and glioma risk: Test of association by genotype
[PMID 21796154] Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze
[PMID 18310477] ORMDL3 gene is associated with asthma in three ethnically diverse populations.
[PMID 18439551] Genetic architecture of transcript-level variation in humans.
[PMID 19175592] Asthma and atopy are associated with chromosome 17q21 markers in Chinese children.
[PMID 19426955] Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 19714205] Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
[PMID 19732864] Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.
[PMID 20187971] Modeling expression quantitative trait loci in data combining ethnic populations.
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
[PMID 20698975] Asthma-susceptibility variants identified using probands in case-control and family-based analyses.
[PMID 21337730] Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.
[PMID 22472724] Asthma and bronchodilator responsiveness are associated with polymorphic markers of ARG1, CRHR2 and chromosome 17q21.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23096927] Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population
[PMID 23157251] Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population
[PMID 22732088] GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.
[PMID 23028483] Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
[PMID 25768087] An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study
[PMID 26886240] Association Between Gasdermin A and Gasdermin B Polymorphisms and Susceptibility to Adult and Childhood Asthma Among Jordanians.
[PMID 28854703] Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases.