|up to 2.1x asthma risk via the ORMDL3 gene|
|(C;C)||2||0.69x lower risk of Childhood Asthma.|
|(C;T)||1.8||Normal risk for Childhood Asthma.|
|(T;T)||2||1.5x increased risk for Childhood Asthma.|
rs7216389, a SNP in the ORMDL3 gene on chromosome 17q21, was associated with susceptibility to childhood asthma in a study of ~1,000 British patients. The variation appears to be linked to altered levels of the ORMDL3 mRNA, which was shown in a cohort study of ~5,000 British and German patients to be correlated to childhood asthma.[PMID 17611496]
A large study of Scottish asthma patients replicated these results, finding that a single copy of the T allele conferred an odds ratio of 1.50 (CI: 1.24-1.81) and 2 copies conferred an odds ratio of 2.11 (CI: 1.71-2.61), respectively.[PMID 18395550]
[PMID 19029000] Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.
[PMID 19133921] Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma
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[PMID 18310477] ORMDL3 gene is associated with asthma in three ethnically diverse populations.
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[PMID 19175592] Asthma and atopy are associated with chromosome 17q21 markers in Chinese children.
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