|up to 2.1x asthma risk via the ORMDL3 gene|
|(C;C)||2||0.69x lower risk of Childhood Asthma.|
|(C;T)||1.8||Normal risk for Childhood Asthma.|
|(T;T)||2||1.5x increased risk for Childhood Asthma.|
A large study of Scottish asthma patients replicated these results, finding that a single copy of the T allele conferred an odds ratio of 1.50 (CI: 1.24-1.81) and 2 copies conferred an odds ratio of 2.11 (CI: 1.71-2.61), respectively.[PMID 18395550]
[PMID 19029000] Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.
[PMID 20372189] A sequence variant on 17q21 is associated with age at onset and severity of asthma
[PMID 19133921] Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma
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[PMID 18310477] ORMDL3 gene is associated with asthma in three ethnically diverse populations.
[PMID 18439551] Genetic architecture of transcript-level variation in humans.
[PMID 19175592] Asthma and atopy are associated with chromosome 17q21 markers in Chinese children.
[PMID 19426955] Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
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[PMID 19714205] Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
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[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
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[PMID 23157251] Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population
[PMID 22732088] GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.
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[PMID 25768087] An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study
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