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rs713598

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 1.1 Can taste bitter.
(C;G) 1.1 Can taste bitter.
(G;G) 1.1 Possibly unable to taste bitter in some foods.
ReferenceGRCh38 38.1/141
Chromosome7
Position141973545
GeneTAS2R38
is asnp
is mentioned by
dbSNPrs713598
dbSNP (classic)rs713598
ClinGenrs713598
ebirs713598
HLIrs713598
Exacrs713598
Gnomadrs713598
Varsomers713598
LitVarrs713598
Maprs713598
PheGenIrs713598
Biobankrs713598
1000 genomesrs713598
hgdprs713598
ensemblrs713598
geneviewrs713598
scholarrs713598
googlers713598
pharmgkbrs713598
gwascentralrs713598
openSNPrs713598
23andMers713598
SNPshotrs713598
SNPdbers713598
MSV3drs713598
GWAS Ctlgrs713598
GMAF0.4692
Max Magnitude1.1
? (C;C) (C;G) (G;G) 28


rs713598 is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the taste of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like coffee and dark beers).

Due to it's minus orientation and nearly 50/50 split of allele frequency it is easily confused.

In the orientation shown in dbSNP and used in SNPedia

In the GRCh37 orientation currently (2017) reported by 23andMe

Tasting is dominant, so heterozygotes are able to taste bitterness.

If you are a "taster", you're also likely to carry at least one rs10246939(C) and one rs1726866(C) allele since, along with rs713598(G), these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.[PMID 12595690]

OMIM607751
DescTASTE RECEPTOR, TYPE 2, MEMBER 38; TAS2R38
Variant
Relatedalso
GWAS snp
PMID [PMID 20675712OA-icon.png]
Trait
Title The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12
Risk Allele
P-val 2E-104
Odds Ratio None None
OMIM607751
Desc
Variant0001
Relatedalso


ClinVar
Risk Rs713598(C;C)
Alt Rs713598(C;C)
Reference Rs713598(G;G)
Significance Drug-response
Disease Phenylthiocarbamide tasting
Variation info
Gene TAS2R38
CLNDBN Phenylthiocarbamide tasting
Reversed 1
HGVS NC_000007.13:g.141673345C>G
CLNSRC OMIM Allelic Variant UniProtKB (protein)
CLNACC RCV000003038.1,



[PMID 15883422] TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study.

[PMID 18248681OA-icon.png] Prevalence of common disease-associated variants in Asian Indians.

[PMID 18834969OA-icon.png] A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.

[PMID 19092995OA-icon.png] Bitter taste receptors influence glucose homeostasis.

[PMID 19687126OA-icon.png] A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.

[PMID 19779476OA-icon.png] Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children.

[PMID 21763010] Implication of the G145C polymorphism (rs713598) of the TAS2r38 gene on food consumption by Brazilian older women.

Bitter Taste Perception


[PMID 24083639OA-icon.png] Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk


[PMID 23133589OA-icon.png] Bitter taste receptor polymorphisms and human aging.


[PMID 25257701OA-icon.png] Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol


[PMID 31137020OA-icon.png] Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis.