| Geno
|
Mag
|
Summary
|
| (A;A)
|
2
|
1.4x increased risk of developing bladder cancer.
|
| (A;G)
|
1.5
|
Normal risk of developing bladder cancer.
|
| (G;G)
|
2
|
Lower (0.83x) risk of developing bladder cancer.
|
rs710521 is a SNP located in chromosome region 3q38, near the TP63 gene.
A study ultimately totaling over 4,000 bladder cancer patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of rs710521(A) were at 1.4x increased risk (allele-specific odds ratio = 1.19, p = 1 x 10e-7) for the disease.[PMID 18794855
]
[PMID 21063684] An additional 1,425 bladder cancer patients, supplemented by a meta-analysis of 5,695 additional cases (and 40,000+ controls), did replicate a (somewhat) increased risk associated with the rs710521(A) allele. The overall odds ratio was 1.18 (OR: 1.12 - 1.25, p < 0.0001).
Another study in Chinese populations did not find an increased risk of bladder cancer for this SNP. [PMID 19369583]
| GWAS snp
|
| PMID
|
[PMID 20972438]
|
| Trait
|
|
| Title
|
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
|
| Risk Allele
|
A
|
| P-val
|
2E-10
|
| Odds Ratio
|
1.1800 [1.12-1.24]
|
[PMID 22994575] Bladder cancer survival in a former industrial area in Saxony-Anhalt, Germany
| GWAS snp
|
| PMID
|
[PMID 24163127]
|
| Trait
|
Bladder cancer
|
| Title
|
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
| Risk Allele
|
A
|
| P-val
|
2E-11
|
| Odds Ratio
|
1.14 [1.10-1.19]
|
[PMID 25218484] Replicative study of GWAS TP63C/T, TERTC/T, and SLC14A1C/T with susceptibility to bladder cancer in North Indians
]
