|rs700651 associated with increased risk of developing intracranial aneurysm.|
|| Normal risk of aneurysm
|| ~1.11x increased risk of intracranial aneurysm
|| ~1.23x increased risk of intracranial aneurysm
|?|| (A;A) (A;G) (G;G) ||28|
a larger meta-analysis in 2013 gave rs700651 a per allele OR of 1.11; 95% CI 1.06 -1.18. See PMC3716358
23andMe blog aneurysm
] Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.
|| Insufficiently evaluated pathogenic
Increased risk of intracranial (brain aneurysm) with certain SNPs. rs700651(G;G) associated with 1.56x risk of developing an intracranial aneurysm (IA). Heterozygote risk is 1.18x. Other SNPs associated with increased risk of developing IA include rs1333040 and rs10958409.
rs10958409 is located on chromosome 9; rs1333040 is located on chromosome 8; rs700651 is located on chromosome 2.
Unfortunately, the first sign of an intracranial aneurysm is rupture. Catastrophic bleeding and death may result. Specific knowledge of risk may influence screening decision. More information: Intracranial aneurysm screening: indications and advice for practice. [PMID 15664544].
[PMID 22476622] Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case-control study in China.