|(C;C)||2||1.95x increased risk of developing Crohn's disease|
|(C;T)||1.5||1.63x increased risk of developing Crohn's disease|
|(T;T)||1||Normal risk of developing Crohn's disease|
The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.63 (CI 1.38-2.25), and for homozygotes, 1.95 (CI 1.43-2.67). [PMID 17554300]
[PMID 18923449] Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22
|Title||Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease|
|Odds Ratio||1.21 [NR]|
[PMID 19587699] Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes
[PMID 19068216] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
[PMID 19422935] Genetic risk profiling and prediction of disease course in Crohn's disease patients.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 19638187] Genetic susceptibility to psoriasis: an emerging picture.
[PMID 19915572] Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
[PMID 20518082] Role of genetics in prediction of disease course and response to therapy.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|Title||Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.|
|Odds Ratio||1.17 [1.11-1.23]|
[PMID 26563541] CDKAL1 gene variants affect the anti-TNF response among Psoriasis patients