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rs663048

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 1 Normal risk of developing lung cancer
(G;T) 2 Significantly increased risk of developing lung cancer
(T;T) 2.5 3x increased risk of developing lung cancer
ReferenceGRCh38 38.1/141
Chromosome22
Position26299111
GeneSEZ6L
is asnp
is mentioned by
dbSNPrs663048
dbSNP (old)rs663048
ClinGenrs663048
ebirs663048
HLIrs663048
Exacrs663048
Gnomadrs663048
Varsomers663048
LitVarrs663048
Maprs663048
PheGenIrs663048
Biobankrs663048
1000 genomesrs663048
hgdprs663048
ensemblrs663048
gopubmedrs663048
geneviewrs663048
scholarrs663048
googlers663048
pharmgkbrs663048
gwascentralrs663048
openSNPrs663048
23andMers663048
23andMe allrs663048
SNPshotrs663048
SNPdbers663048
MSV3drs663048
GWAS Ctlgrs663048
GMAF0.2071
Max Magnitude2.5
? (G;G) (G;T) (T;T) 28

rs663048 associated with lung cancer

The homozygotes for the variant allele had more than a 3-fold risk compared with the wild-type homozygotes [combined odds ratio (OR), 3.32; 95% confidence interval (95% CI), 1.81-7.21]. Heterozygotes also had a significantly elevated risk of lung cancer from the combined replication studies with an OR of 1.15 (95% CI, 1.04-1.59). The effect remained significant after adjusting for age, gender, and pack-years of tobacco smoke.007;67(17):8406-11]. [PMID 17804757]