rs6495446, an intronic SNP in the MTHFS gene, was associated with increased risk for chronic kidney disease based on a study associated with the Framingham Heart Study of ~1,000 Caucasian individuals. The odds ratio rs6495446(C) allele was 1.24 (CI: 1.09-1.41, p=0.001).news 23andMe reports this same information with a different emphasis since the T allele is the minor allele in both European and Asian populations: each T allele lowers the odds of chronic kidney disease by 0.8 times. [PMID 18522750]
|(C;C)||1||normal, but increased risk for chronic kidney disease|
|(C;T)||1.4||0.8x reduced risk for chronic kidney disease|
|(T;T)||2||0.64x reduced risk for chronic kidney disease|
[PMID 21895484] The impact of 5,10-methenyltetrahydrofolate synthetase polymorphism on diabetic nephropathy in the Taiwanese population.