|(C;C)||1.5||higher HDL cholesterol but lower risk for age-related macular degeneration|
|(C;T)||2.5||3x higher risk for age-related macular degeneration|
|(T;T)||2||lower HDL cholesterol but higher risk for age-related macular degeneration|
In a case-control study of two Caucasian populations totaling 2,498 patients, rs5888(C;T) heterozygotes had an increased odds ratio of 2.9 (CI: 1.6-5.3, p<0.002) for age-related macular degeneration (ARMD) based on a pooled analysis. Subgroup analysis indicated that the odds ratio for exudative forms of ARMD was even higher (3.6; CI: 1.7-7.6, p>0.0015) for rs5888(C;T) heterozygotes. [PMID 19806217]
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