|?|| (A;A) (A;G) (G;G) ||28|
|| [PMID 19303062]
|| Folate pathway vitamins
|| Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations
| Risk Allele
| Odds Ratio
|| 27.62 [11.65-43.59] pg/mL increase
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. [PMID 19744961
] G allele associated with lower serum Vitamin B12. "The TCN1 rs526934 G variant may reduce transport of cobalamin, resulting in lower plasma vitamin B12 levels."
[PMID 27901035] This large study (over 50,000 people) found no evidence for "positive association of homocysteine or negative associations of folate and vitamin B12 with CAD/MI".
[PMID 17119116] Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.
[PMID 19064790] Predictive genomics of cardioembolic stroke.