rs501120

minus

Geno	Mag	Summary
(A;A)	1.5	common, but >1.3x increased risk for heart disease
(A;G)	1.3	1.3x increased risk for heart disease
(C;C)	0
(G;G)		normal

Reference

GRCh38 38.1/142

Chromosome

10

Position

44258419

is a	snp
is	mentioned by
dbSNP	rs501120
dbSNP (classic)	rs501120
ClinGen	rs501120
ebi	rs501120
HLI	rs501120
Exac	rs501120
Gnomad	rs501120
Varsome	rs501120
LitVar	rs501120
Map	rs501120
PheGenI	rs501120
Biobank	rs501120
1000 genomes	rs501120
hgdp	rs501120
ensembl	rs501120
geneview	rs501120
scholar	rs501120
google	rs501120
pharmgkb	rs501120
gwascentral	rs501120
openSNP	rs501120
23andMe	rs501120
SNPshot	rs501120
SNPdbe	rs501120
MSV3d	rs501120
GWAS Ctlg	rs501120

GMAF

0.2833

Max Magnitude

1.5

?

(A;A) (A;G) (G;G)

28

rs501120 is a SNP found to be associated with heart disease in two populations by the German MI (Myocardial infarction) Family Study group. The risk allele in dbSNP orientation is rs501120(A). The odds ratio per allele is 1.33 (CI: 1.20-1.48, adjusted p=0.0248).[PMID 17634449 ]

[PMID 23666823] Genetic variants on chromosome 10q11.21 are associated with ischemic stroke in the northern Chinese Han population.

[PMID 23202125 ] Large-scale association analysis identifies new risk loci for coronary artery disease.

[PMID 22386691] Lack of association between the CXCL12 rs501120 polymorphism and cardiovascular disease in Spanish patients with rheumatoid arthritis.

[PMID 22042884 ] Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.

[PMID 21804106 ] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

[PMID 21415067 ] The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels

[PMID 21242481 ] Genetic risk score and risk of myocardial infarction in Hispanics.

[PMID 20847302] Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.

[PMID 20694560] Common genetic polymorphisms in Moyamoya and atherosclerotic disease in Europeans

[PMID 20098575 ] Genetics and cardiovascular disease: Design and development of a DNA biobank.

[PMID 20017983 ] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.

[PMID 19956433 ] Genetics of coronary artery disease: focus on genome-wide association studies.

[PMID 19955471 ] Genetic Variants Identified in a European Genome-Wide Association Study That Were Found to Predict Incident Coronary Heart Disease in the Atherosclerosis Risk in Communities Study

[PMID 19750184 ] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

[PMID 19164808 ] Large scale association analysis of novel genetic loci for coronary artery disease

[PMID 18979498 ] The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.

[PMID 18780302 ] Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

GWAS snp
PMID	[PMID 17634449 ]
Trait	Coronary heart disease
Title	Genomewide association analysis of coronary artery disease.
Risk Allele	T
P-val	9E-8
Odds Ratio	1.33 [1.20-1.48]

GWAS snp
PMID	[PMID 24262325 ]
Trait	Coronary artery disease
Title	Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Risk Allele	C
P-val	2E-6
Odds Ratio	1.09 [1.05-1.14]

[PMID 31804579 ] The Mediterranean diet reduces the genetic risk of chromosome 9p21 for myocardial infarction in an Asian population community cohort.

[PMID 31862910 ] The CXCL12 SNPs and their haplotypes are associated with serum lipid traits.

[PMID 32858814 ] Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population.