||2.1x risk for Aspirin Induced Asthma. But possibly lower risk of lupus and intractable Graves' disease.
||2.1x risk for Aspirin Induced Asthma. But possibly lower risk of intractible Grave's disease.
||Lower risk of Aspirin Induced Asthma. Normal (higher) risk of lupus and intractable Grave's Disease.
|?|| (C;C) (C;T) (T;T) ||28|
rs4794067(C;C) and rs4794067(C;T) genotypes for the TBX21 gene are calculated to be at 2.15 fold higher risk (CI: 1.26-3.64) for aspirin-induced asthma (AIA) compared to rs4794067(T;T) homozygotes, based on a study of 72 patients vs 640 controls in a study of a Japanese population. [PMID 15806396]
Note that in this population, but perhaps not others, linkage disequilibrium exists between this SNP located upstream of the gene, rs4794067, and a common synonymous SNP located in the first exon, rs2074190, with a predictive accuracy of 92%.
On the other hand, rs4794067(C;C) may greatly decrease the risk of lupus if rs17250932(C;C) is also present (at least in Chinese people). [PMID 20429676] And those 2 SNPs also reduce the risk of intractable Graves' disease (at least in Japanese people). [PMID 22014209]
[PMID 25832120] TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic bacterial infection