||1.5x increased risk for open angle glaucoma
||2.2x increased risk for open angle glaucoma
rs4656461 is a SNP near the TMCO1 gene.
A (GWA) study for open-angle glaucoma (OAG) blindness ultimately based on ~1500 cases concluded that the rather rare rs4656461(G) allele was statistically associated with the condition, with a per allele odds ratio of 1.5 (CI: 1.35–1.68, p = 6 × 10e?14).[PMID 21532571]
[PMID 22714896] Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterisation of the protein in the eye
[PMID 25711633] Genetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population