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rs4148739

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 possibly normal probability of remission for inpatients on certain antidepressants
(A;G) 1 possibly, inpatients more likely to remit on certain antidepressants
(G;G) 1 possibly, inpatients more likely to remit on certain antidepressants
ReferenceGRCh38 38.1/141
Chromosome7
Position87531733
GeneABCB1
is asnp
is mentioned by
dbSNPrs4148739
dbSNP (old)rs4148739
ClinGenrs4148739
ebirs4148739
HLIrs4148739
Exacrs4148739
Gnomadrs4148739
Varsomers4148739
LitVarrs4148739
Maprs4148739
PheGenIrs4148739
Biobankrs4148739
1000 genomesrs4148739
hgdprs4148739
ensemblrs4148739
gopubmedrs4148739
geneviewrs4148739
scholarrs4148739
googlers4148739
pharmgkbrs4148739
gwascentralrs4148739
openSNPrs4148739
23andMers4148739
23andMe allrs4148739
SNPshotrs4148739
SNPdbers4148739
MSV3drs4148739
GWAS Ctlgrs4148739
GMAF0.1318
Max Magnitude1
? (A;A) (A;G) (G;G) 28

rs4148739 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and their efficacy or potential for adverse side effects. However, the link between the increased brain concentrations of antidepressants and a clinically significant response is unconfirmed. In clinic, even the lower concentrations of drugs may achieve sufficient antidepressant effect, and the dose of the drug can be adjusted upwards until the patient responds. According to a recent review [PMID 27918249], ten studies reported that ABCB1 SNPs have clinical effect in depression and eight that they do not.

rs4148739 is one of 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below.

When treated for depression with citalopram, paroxetine, amitriptyline, or venlafaxine (substrates of the protein encoded by ABCB1), a highly statistically significant association between the overall genetic variability of these SNPs and the remission was reported by Uhr et al in a study of ~400 German inpatients.10.1016/j.neuron.2007.11.017 However, this result has to be treated with caution. A well-run, double-blind study of ABCB1 substrate citalopram in depression (STAR-D study) and a following meta-analysis [PMID 25847751] failed to replicate several Uhr et al. results for other ABCB1 SNPs.

The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017:


[PMID 24192121] ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients