|?|| (A;A) (A;T) (T;T) ||28|
has been reported in a large study to be associated with heart disease
, in particular, coronary artery disease
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.60 (CI 1.16-2.21), and for homozygotes, 1.92 (CI 1.40-2.63). [PMID 17554300]
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 21804106] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.
[PMID 26436499] Male-specific association of the APC rs383830 T allele with the risk of coronary heart disease