||Normal (worse) aging.
||Less mental decline with age.
||Increased longevity. Less mental decline with age.
rs3758391, a SNP in the SIRT1 gene, has been reported to potentially have some role in either longevity, or with higher statistical significance, better cognitive function in older individuals. SIRT1 is thought to regulate neuronal metabolism and survival in response to stress, and the equivalent gene in other species influences maximal life span. The study reporting improved cognition for carriers of rs3758391(T) alleles was based on over 1,000 Finnish adults over the age of 85, and a weak trend towards lower cardiovascular disease was also reported for this allele. [PMID 17895433]
[PMID 20503258] Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City
[PMID 20633545] SIRT1 variants are associated with aging in a healthy Han Chinese population
[PMID 23450480] [Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi]
[PMID 27089876] [Common variants in SIRT1 and human longevity in a Chinese population]
[PMID 28919817] SIRT1 gene polymorphisms and risk of lung cancer.
[PMID 30377410] SIRT1 rs3758391 polymorphism and risk of diffuse large B cell lymphoma in a Chinese population.
[PMID 32849821] A Comprehensive Analysis of the Effect of SIRT1 Variation on the Risk of Schizophrenia and Depressive Symptoms.
[PMID 32967053] SIRT1 Gene SNP rs932658 is Associated with Medication-Related Osteonecrosis of the Jaw.