| Geno
|
Mag
|
Summary
|
| (A;A)
|
1
|
Normal risk of developing rheumatoid arthritis
|
| (A;C)
|
2
|
1.94x risk of developing rheumatoid arthritis
|
| (C;C)
|
2.5
|
1.94x risk of developing rheumatoid arthritis
|
rs3738919, a SNP located in the ITGAV gene, was identified in a European study to be associated with rheumatoid arthritis (RA). [PMID 17615072
]
The risk allele for rs3738919 is the more common allele, (C). For the three European Caucasian populations studied (372 RA patients + 330 controls), and combining the (C;C) and (A;C) genotypes in comparison to the (A;A) genotype, the odds ratio for RA = 1.94 (CI: 1.3–2.9, p = 0.002). There was no significant difference in RA risk between those carrying one or two (C) alleles. [PMID 17615072]
An editorial about this finding has been published. [PMID 18001496]
[PMID 19818132] The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets
]
