Geno

Mag

Summary

(C;C)

2

0.6x decreased risk for cervical cancer, but 1.4x increased risk for HNSCC and 1.8x increased risk for breast cancer

(C;T)

2

0.5x decreased risk for cervical cancer, HNSCC, and breast cancer

(T;T)

3

1.5x  2x increased risk for cervical cancer, HNSCC, and breast cancer

?  (C;C) (C;T) (T;T)  28 

rs3738579 represents a SNP in the 5' UTR region upstream of the RNASEL gene.
A study of patients diagnosed with carcinoma of the uterine cervix, head and neck squamous cell carcinomas (HNSCC), and breast cancer found 1.5x2x increased risk for all three cancer types for the rs3738579(T;T) genotype, while finding decreased risk (0.5x) for rs3738579(C;T) heterozygotes. rs3738579(C;C) homozygotes had 0.6x less risk for cervical cancer but increased risk for HNSCC (1.4x) and breast cancer (1.8x).[PMID 18575592]
Although statistics were not reported per genotype, a combination of data from all three cancer forms over all genotypes provided strong statistical evidence for rs3738579 as a cancer marker, with a pvalue of 4.43x10(5).[PMID 18575592]