||0.6x decreased risk for cervical cancer, but 1.4x increased risk for HNSCC and 1.8x increased risk for breast cancer (reported in 2008)
||0.5x decreased risk for cervical cancer, HNSCC, and breast cancer (reported in 2008)
||1.5x - 2x increased risk for cervical cancer, HNSCC, and breast cancer (reported in 2008)
rs3738579 represents a SNP in the 5' UTR region upstream of the RNASEL gene.
A study of patients diagnosed with carcinoma of the uterine cervix, head and neck squamous cell carcinomas (HNSCC), and breast cancer found 1.5x-2x increased risk for all three cancer types for the rs3738579(T;T) genotype, while finding decreased risk (0.5x) for rs3738579(C;T) heterozygotes. rs3738579(C;C) homozygotes had 0.6x less risk for cervical cancer but increased risk for HNSCC (1.4x) and breast cancer (1.8x).[PMID 18575592]
Although statistics were not reported per genotype, a combination of data from all three cancer forms over all genotypes provided strong statistical evidence for rs3738579 as a cancer marker, with a p-value of 4.43x10(-5).[PMID 18575592]
Note that the research cited above was published over a decade ago, and there has been no follow-up or replication to our knowledge. It would be best to consider the research preliminary and perhaps of little to no clinical significance (until it is confirmed or replicated in a larger sample).