|(C;T)||2||1.2x increased risk for prostate cancer|
|(T;T)||2.9||2x increased prostate cancer risk; among breast cancer patients, herceptin is less effective|
|?||(C;C) (C;T) (T;T)||28|
rs351855, a SNP in the fibroblast growth factor receptor 4 (FGFR4) gene, is also known as the Gly388Arg variant. The rs351855(T) allele encodes the risk (Arg) allele.
The Arg form of this SNP is likely to cause a harder to treat version of node-positive breast cancer, including reducing the efficacy of Herceptin, based on a study of 372 patients.[PMID 16822847]
A study of ~500 Japanese prostate cancer patients found that individuals with a rs351855(T;T) genotype had a 2.2- and 1.9-fold increased risk of prostate cancer and benign prostate hyperplasia (BPH), and a 1.8-fold increased risk of metastatic prostate cancer compared to the (C;C) genotype.[PMID 18756523]
A meta-analysis published in 2011, surveying a total of 2,618 cases of prostate cancer, concluded that the odds ratio per rs351855(T) allele was 1.17 (CI: 1.07 - 1.29), and that when stratified by race, Caucasians and Asians were at highest risk.[PMID 21349172]
[PMID 18762813] ~1500 prostate cancer patients showed only a weak association between rs351855 and prostate-cancer specific mortality, and no evidence associating it with prostate cancer risk, disease aggressiveness, Gleason score, or stage.
[PMID 21412156] Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor
[PMID 21656577] Association between fibroblast growth factor receptor 4 polymorphisms and risk of hepatocellular carcinoma
[PMID 22271411] Pharmacogenetics of the Effects of Colesevelam on Colonic Transit in Irritable Bowel Syndrome with Diarrhea.
[PMID 22313031] Fibroblast Growth Factor Receptor 4 Polymorphisms and Susceptibility to Coronary Artery Disease.
[PMID 22696188] Fibroblast growth factor receptor 4 polymorphisms and coronary artery disease: a case control study
|Disease||Cancer progression and tumor cell motility|
|CLNDBN||Cancer progression and tumor cell motility|
|CLNSRC||OMIM Allelic Variant UniProtKB (protein)|
[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 19500394] Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
[PMID 21396369] A Klothobeta variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea.
[PMID 23206452] Association between Fibroblast Growth Factor Receptor 4 Gly388Arg Polymorphism and Ischaemic Stroke
[PMID 24381107] Fibroblast growth factor receptor 4 polymorphisms and the prognosis of non-Hodgkin lymphoma
[PMID 23524567] FGFR4 genetic polymorphisms determine the chemotherapy response of Chinese patients with non-small cell lung cancer
[PMID 26431494] Association of FGFR3 and FGFR4 gene polymorphisms with breast cancer in Chinese women of Heilongjiang province
[PMID 31878098] Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma.