rs2943641
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | increased risk for type 2 diabetes | |
| (C;T) | increased risk for type 2 diabetes |
| Make rs2943641(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 226229029 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2943641 |
| dbSNP (classic) | rs2943641 |
| ClinGen | rs2943641 |
| ebi | rs2943641 |
| HLI | rs2943641 |
| Exac | rs2943641 |
| Gnomad | rs2943641 |
| Varsome | rs2943641 |
| LitVar | rs2943641 |
| Map | rs2943641 |
| PheGenI | rs2943641 |
| Biobank | rs2943641 |
| 1000 genomes | rs2943641 |
| hgdp | rs2943641 |
| ensembl | rs2943641 |
| geneview | rs2943641 |
| scholar | rs2943641 |
| rs2943641 | |
| pharmgkb | rs2943641 |
| gwascentral | rs2943641 |
| openSNP | rs2943641 |
| 23andMe | rs2943641 |
| SNPshot | rs2943641 |
| SNPdbe | rs2943641 |
| MSV3d | rs2943641 |
| GWAS Ctlg | rs2943641 |
| GMAF | 0.2686 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 19734900] Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
10.1371/journal.pone.0026911 identified a significant association of rs2943641 near IRS1 locus, with type 2 diabetes in the Japanese population.
[PMID 22576021] Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population
[PMID 21917432
] IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.
[PMID 22253814] A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme
[PMID 20043853] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
[PMID 21353221] The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.
[PMID 21747052] Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.
[PMID 23418314] The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals
[PMID 23036851] Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors
[PMID 23659870] Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study
[PMID 24255076] Circulating 25-Hydroxyvitamin D, IRS1 Variant rs2943641, and Insulin Resistance: Replication of a Gene-Nutrient Interaction in 4 Populations of Different Ancestries
[PMID 24493031] Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population
[PMID 26582067] Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis
