rs2881766

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	1	Normal risk for pregnancy-induced hypertension
(G;T)	1.5	Slightly increased risk for pregnancy-induced hypertension
(T;T)	1.5	Slightly increased risk for pregnancy-induced hypertension

Reference

GRCh38 38.1/141

Chromosome

6

Position

151797984

Gene

ESR1

is a	snp
is	mentioned by
dbSNP	rs2881766
dbSNP (classic)	rs2881766
ClinGen	rs2881766
ebi	rs2881766
HLI	rs2881766
Exac	rs2881766
Gnomad	rs2881766
Varsome	rs2881766
LitVar	rs2881766
Map	rs2881766
PheGenI	rs2881766
Biobank	rs2881766
1000 genomes	rs2881766
hgdp	rs2881766
ensembl	rs2881766
geneview	rs2881766
scholar	rs2881766
google	rs2881766
pharmgkb	rs2881766
gwascentral	rs2881766
openSNP	rs2881766
23andMe	rs2881766
SNPshot	rs2881766
SNPdbe	rs2881766
MSV3d	rs2881766
GWAS Ctlg	rs2881766

GMAF

0.4118

Max Magnitude

1.5

?	(G;G) (G;T) (T;T)	28

rs2881766 is a SNP in the promoter region of the estrogen receptor alpha ESR1 gene.

Carriers of rs2881766(T) alleles are at somewhat (slightly) higher risk for pregnancy-induced hypertension.[PMID 18360040]

[PMID 18408366] Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.

[PMID 18636124] Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.

[PMID 25323936] Genetic polymorphism of ESR1 rs2881766 increases breast cancer risk in Korean women

[PMID 26850117] The association between a novel polymorphism (rs1062577) in ESR1 and breast cancer susceptibility in the Han Chinese women.