|Associated with increased susceptibility to alcohol withdrawal symptoms and ADHD.|
|(C;C)||2||2x risk of severe alcohol withdrawal. Possible increased odds of ADHD.|
|(C;T)||1.9||Lower risk of alcohol withdrawal seizures, and perhaps lower odds of ADHD.|
|(T;T)||1.9||Lower risk of alcohol withdrawal seizures, and probably lower odds of ADHD.|
|?||(C;C) (C;T) (T;T)||28|
rs27072, a SNP in the dopamine transporter SLC6A3 gene, has been associated with more severe symptoms upon alcohol withdrawal, such as seizures, in a study of 250 Caucasian alcohol-dependent patients. Two haplotypes appear to be tagged by this SNP and a neighbor, rs27048. The rs27072 polymorphism has been shown to be significantly associated with ADHD in clinical samples of Canadian children aged 6 to 16 [Feng et al., 2005] and the significant association was also reported by Ouellet-Morin et al. in a Canadian twin study, 2008 (Am. J. of Medical Genetics Part B, 147B:1442-1449 (2008). [PMID 18070248]
|Desc||SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, DOPAMINE),|
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